Programmable Nano-Bio-Chip Sensors: Analytical Meets Clinical

Innovative Programmable Bio-Nano-Chip Digitizes Biology Using Sensors That Learn Bridging Biomarker Discovery and Clinical Implementation

The lack of standard tools and methodologies and the absence of a streamlined multimarker approval process have hindered the translation rate of new biomarkers into clinical practice for a variety of diseases afflicting humankind. Advanced novel technologies with superior analytical performance and reduced reagent costs, like the programmable bio-nano-chip system featured in this article, have ...

Programmable bio-nano-chip systems for serum CA125 quantification: toward ovarian cancer diagnostics at the point-of-care.

Point-of-care (POC) implementation of early detection and screening methodologies for ovarian cancer may enable improved survival rates through early intervention. Current laboratory-confined immunoanalyzers have long turnaround times and are often incompatible with multiplexing and POC implementation. Rapid, sensitive, and multiplexable POC diagnostic platforms compatible with promising early ...

Performance Comparison of Peak Detection Algorithm for Nano-bio Sensors

Sensitive and selective sensor system is required to detect causes of disease. It is able to detect the cause of the disease more effectively by using multi-modal properties of nano-bio sensors. Some peak detection algorithms which are suitable for implementing with micro-controller are compared to apply to multi-modal nano-bio sensors in this paper. It is shown that autothreshold peak detectio...

P450-Based Nano-Bio-Sensors for Personalized Medicine

Cytochromes P450 (P450s or CYPs) belong to a multigene family of more than 3,000 heme proteins which catalyse the NADPH-dependent monooxygenation and other about 60 distinct classes of biotransformation reactions. Cytochromes P450 are known to be involved in the metabolism of over 1,000,000 different xenobiotic and endobiotic lipophilic substrates (Shumyantseva, Bulko, Archakov, 2005). Cytochro...

Bio-Electronics and Bio-sensors